The universe exists just so, by itself. Its inherent self-organizing property, capable of forming organisms and intellect, does not mean that it has a predetermined purpose. This causeless and purposeless property and without it, intelligent beings would not have emerged, asking questions.
Which questions will remain unanswered by scientists? There are no questions that science will not eventually be able to comprehend and explain, it is only a matter of time. There may be certain details that are not crucial for understanding the overall picture of the world. For instance, perhaps, science may never give an exact answer to the question: How much time has passed before self-organizing matter appeared?, but since that period was the Era of Nothing, the concept of time loses its meaning, and therefore the answer to this question is not so important.
Not only the anatomy of all living beings, including humans, is a corresponding arrangement of physical particles, but also their fundamental and all other properties.
For arguing the theses of metaphysical naturalism, it is not at all necessary to define the beginning of time, the finiteness of the Universe, or how a living molecule appeared on Earth, other facts indicating the natural causeless development of events are more than sufficient: life on planet Earth could not have originated; evolution has no purpose; mass extinctions in the history of life; the vast number of extinct species; the specifics of the life of hominids and the earliest humans; the function of the human mind at its inception; the high probability of the extinction of all life, not only in the past but also today; the entire logic of human history; all its sufferings, pains, and achievements; the continuity of the appearance of various teachings and moral norms, and much more.
The thought that "in the Universe, there likely already exist or will definitely form advanced sublime intelligent beings" arouses delight and increases spiritual satisfaction.